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Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems
Published on: July 4, 2011
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Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing.
Joseph K-H Wong1, Matthew H Todd2, Peter J Rutledge3
1School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia. joseph.wong@sydney.edu.au.
Molecules (Basel, Switzerland)
|January 27, 2017
Summary
This review highlights recent advancements in small-molecule fluorescent probes for chemical sensing. It focuses on macrocyclic receptors like cyclam and calixarenes for detecting various analytes.
Area of Science:
- Chemical Sensing
- Analytical Chemistry
- Supramolecular Chemistry
Background:
- Small-molecule fluorescent probes are crucial for chemical sensing, integrating receptor and reporter units.
- Binding events are signaled by fluorescence changes via mechanisms like PET, CT, FRET, AIE, and ACQ.
- These probes detect diverse analytes including ions, carbohydrates, and biomolecules.
Purpose of the Study:
- To review significant new fluorescence-based probes developed in the last five years.
- To focus on probes utilizing macrocyclic recognition components.
- To discuss probes based on cyclam, calixarenes, cyclodextrins, and crown ethers, alongside other receptor types.
Main Methods:
- Literature review of fluorescence-based chemical sensors.
- Analysis of probes employing macrocyclic receptors (cyclam, calixarenes, cyclodextrins, crown ethers).
- Inclusion of systems with other macrocyclic and non-macrocyclic recognition units.
Main Results:
- Identification of novel fluorescence-based probes for various analytes.
- Emphasis on the utility of macrocyclic receptors in probe design.
- Overview of diverse sensing mechanisms and their applications.
Conclusions:
- Macrocyclic receptors, particularly cyclam, calixarenes, cyclodextrins, and crown ethers, are central to modern fluorescent probe development.
- Recent advancements have expanded the scope and sensitivity of fluorescence-based chemical sensing.
- This review provides a valuable resource for researchers in the field.
