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Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum
D J Surmeier1, J Bargas, S T Kitai
1Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163.
Neuroscience Letters
|September 11, 1989
Abstract:
Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell variant of the patch clamp technique, we have found that two types of A-current are expressed in rat neostriatal neurons, one that is similar to previous descriptions in mammals and a second that is activated at considerably more depolarized potentials.