Related Experiment Videos
Functional difference in monoamine transmitters in the behaviorally abnormal mouse mutant (wriggle mouse sagami)
K Ishikawa1, S Shibanoki, T Kubo
1Department of Pharmacology, Nihon University School of Medicine, Tokyo, Japan.
Neuroscience Letters
|September 11, 1989
Summary
Neurological disorders in WMS mice stem from neurotransmitter imbalances. Specifically, altered serotonin, dopamine, and norepinephrine levels contribute to their movement abnormalities.
Area of Science:
- Neuroscience
- Genetics
- Pharmacology
Background:
- A spontaneous mutant mouse, wriggle mouse sagami (WMS), exhibits neurological disorders.
- Clinical signs include tremor, dystonia, and involuntary movements, suggesting a central nervous system defect.
Purpose of the Study:
- To investigate the role of neurotransmitter systems in the neurological deficits of WMS mice.
- To quantify levels and turnover rates of key neurotransmitters and their metabolites in specific brain regions.
Main Methods:
- High-performance liquid chromatography with electrochemical detection was used for simultaneous measurement.
- Neurotransmitter concentrations and metabolite levels were analyzed in dissected brain regions of WMS and control BALB/c mice.
Main Results:
- WMS mice showed significantly higher serotonin turnover in multiple brain regions.
- Increased intrastriatal dopamine and its metabolites were observed, without altered turnover.
- Norepinephrine levels increased, but turnover decreased in the cerebellum of WMS mice.
Conclusions:
- The study indicates multiple disturbances in neurotransmitter systems contribute to the neurological phenotype of WMS mice.
- These findings highlight the complex interplay of neurotransmitters in motor control and neurological function.