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Updated: Mar 8, 2026
06:46
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
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Transition-Metal-Catalyzed C-H Alkylation Using Alkenes
Zhe Dong1,2, Zhi Ren2, Samuel J Thompson2
1Department of Chemistry, University of Chicago , Chicago, Illinois 60637, United States.
Chemical Reviews
|January 27, 2017
Summary
This review covers transition-metal-catalyzed alkylation reactions using olefins. It focuses on cost-effective and sustainable methods for forming carbon-carbon bonds via C-H or olefin activation.
Area of Science:
- Organic Chemistry
- Catalysis
- Sustainable Chemistry
Background:
- Alkylation reactions are crucial for C-C bond formation.
- Conventional alkylating agents pose cost and sustainability challenges.
- Unactivated olefins offer a more economical and greener alternative.
Purpose of the Study:
- To review transition-metal-catalyzed alkylations using unactivated olefins.
- To summarize methods for C-H bond addition across olefins.
- To cover literature up to May 2016.
Main Methods:
- Review of transition-metal-catalyzed reactions.
- Categorization based on activation mode: C-H activation and olefin activation.
- Focus on reactions involving regular olefins and 1,3-dienes.
Main Results:
- Detailed summary of various C-H alkylation strategies.
- Exploration of olefin activation pathways for alkylation.
- Highlighting the utility of olefins as alkylating agents.
Conclusions:
- Transition-metal catalysis enables efficient C-H alkylation with olefins.
- Olefins provide a sustainable and cost-effective approach to C-C bond formation.
- This review consolidates key developments in olefin-based alkylation up to 2016.
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