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Effects of fenoterol on the skeletal system depend on the androgen level

Leszek Śliwiński1, Urszula Cegieła1, Maria Pytlik1

  • 1Department of Pharmacology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.

Pharmacological Reports : PR
|January 28, 2017
PubMed
Abstract

Insights

Fenoterol, a sympathetic nervous system drug, damaged bone in normal rats but protected against bone loss in testosterone-deficient rats, highlighting its complex role in bone remodeling.

Area of Science:

  • Pharmacology
  • Endocrinology
  • Bone Biology

Background:

  • The sympathetic nervous system's role in bone remodeling remains incompletely understood.
  • Investigating the impact of beta-2 adrenergic agonists on skeletal health is crucial.

Purpose of the Study:

  • To investigate the effects of fenoterol on bone microarchitecture and remodeling.
  • To determine fenoterol's impact in both normal and androgen-deficient states.
  • To elucidate the drug's mechanism in osteoclastogenesis.

Main Methods:

  • In vivo studies using normal and orchidectomized rats treated with fenoterol.
  • In vitro investigation of osteoclastogenesis and mRNA expression in mouse osteoblast cell cultures.
  • Analysis of bone microarchitecture and cellular responses.

Main Results:

  • Fenoterol impaired bone microarchitecture in rats with normal androgen levels.
  • In androgen-deficient rats, fenoterol mitigated osteoporosis-related bone damage.
  • In vitro, fenoterol promoted osteoclastogenesis with testosterone but inhibited it without testosterone.

Conclusions:

  • Fenoterol exhibits a dual effect on bone: detrimental in the presence of androgens and protective in their absence.
  • These findings underscore the sympathetic nervous system's significant role in regulating bone remodeling.
  • Fenoterol's differential effects suggest potential therapeutic applications in specific hormonal conditions.
Keywords:
AndrogensBoneFenoterolOsteoblastsOsteoclasts

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