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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Mar 8, 2026

Teratoma Generation in the Testis Capsule
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Teratoma Generation in the Testis Capsule

Published on: November 7, 2011

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Growing Teratoma Syndrome.

S P Kataria1, Ankur Nandan Varshney1, Mukesh Nagar1

  • 1Department of Medical Oncology, Vardhman Mahavir Medical College and Safdurjung Hospital, New Delhi, 110029 India.

Indian Journal of Surgical Oncology
|January 28, 2017
PubMed
Summary
This summary is machine-generated.

Growing teratoma syndrome (GTS) is a rare condition where benign tumors grow after chemotherapy. This case highlights that surgery, not further chemotherapy, is the cure for this chemo-resistant disease.

Keywords:
Benign metastasisChemotherapeutic retroconversionGrowing teratoma syndromeTeratoma

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Growing teratoma syndrome (GTS) is an infrequent complication post-chemotherapy.
  • It is often misdiagnosed as progressive disease due to unfamiliarity.
  • GTS is characterized by benign metastases that increase in size and number.

Purpose of the Study:

  • To present a case of ovarian immature teratoma with Growing Teratoma Syndrome.
  • To emphasize the diagnostic challenges and clinical characteristics of GTS.
  • To highlight surgery as the definitive curative treatment for GTS.

Main Methods:

  • Case report of a patient with ovarian immature teratoma.
  • Post-chemotherapy evaluation including imaging and surgical resection.
  • Pathological examination of the resected specimen.

Main Results:

  • The patient presented with increasing tumor size after chemotherapy.
  • Resected specimen confirmed mature teratoma, indicative of Growing Teratoma Syndrome.
  • Surgical intervention led to a complete cure.

Conclusions:

  • Growing Teratoma Syndrome requires recognition of its distinct clinical behavior.
  • Chemo-resistance and radio-resistance necessitate surgical management.
  • Surgical resection provides a curative outcome for Growing Teratoma Syndrome.