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Platelets and Platelet-Derived Microvesicles as Immune Effectors in Type 2 Diabetes
Nancy Cortez-Espinosa1, Laura Perez-Campos Mayoral2, Eduardo Perez-Campos1
1Centro de Investigación Facultad de Medicina-UNAM-UABJO, Oaxaca, Mexico.
Current Vascular Pharmacology
|January 28, 2017
Summary
Type 2 diabetes mellitus (T2DM) and inflammation increase platelet activity, potentially worsening vascular disease. Platelets release microvesicles that influence immune cells, impacting T2DM development.
Area of Science:
- Immunology
- Endocrinology
- Vascular Biology
Background:
- Systemic inflammation is linked to type 2 diabetes mellitus (T2DM).
- Inflammation may enhance platelet reactivity and vascular disease progression.
- Platelets and their microvesicles play a role in cell-to-cell communication.
Purpose of the Study:
- To examine the influence of platelets and platelet-derived microvesicles on immune cells.
- To explore the role of these interactions in the pathogenesis of T2DM.
Main Methods:
- Review of current literature on platelet function, microvesicles, and T2DM.
- Analysis of mechanisms by which platelets and microvesicles interact with immune cells.
Main Results:
- Platelets release microvesicles containing bioactive molecules.
- These microvesicles can modulate immune cell function.
- This interaction contributes to the inflammatory processes in T2DM.
Conclusions:
- Platelets and their microvesicles are key mediators in the immune response associated with T2DM.
- Understanding these interactions may offer new therapeutic targets for T2DM and its vascular complications.
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