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Updated: Mar 8, 2026

Analysis of Zebrafish Larvae Skeletal Muscle Integrity with Evans Blue Dye

Analysis of Zebrafish Larvae Skeletal Muscle Integrity with Evans Blue Dye

Published on: November 30, 2015

Muscular dystrophy modeling in zebrafish.

M Li¹, K J Hromowyk², S L Amacher²

¹Monash University, Clayton, VIC, Australia.

Methods in Cell Biology

|January 29, 2017

Summary

This summary is machine-generated.

Zebrafish offer a powerful new model for studying inherited muscle disorders like muscular dystrophies (MDs). These models aid in understanding disease mechanisms and screening for effective drug therapies.

Keywords:

Chemical screen Dystrophin Human disease modeling Myogenesis Skeletal muscle Zebrafish

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Analysis of Zebrafish Larvae Skeletal Muscle Integrity with Evans Blue Dye

Analysis of Zebrafish Larvae Skeletal Muscle Integrity with Evans Blue Dye

Published on: November 30, 2015

Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae

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Published on: July 23, 2013

Examining Muscle Regeneration in Zebrafish Models of Muscle Disease

Examining Muscle Regeneration in Zebrafish Models of Muscle Disease

Published on: January 18, 2021

Area of Science:

Muscle Biology and Genetics
Comparative Medicine
Pharmacology

Background:

Inherited muscle disorders, including muscular dystrophies (MDs), stem from genetic defects affecting skeletal muscle.
Rodent models have advanced understanding of MD pathogenesis but show limitations in human disease translation.
Novel animal models are needed to better study MDs and develop therapies.

Purpose of the Study:

To review the utility of zebrafish as a model for human inherited muscle disorders.
To discuss zebrafish myogenesis and larval muscle characteristics relevant to MDs.
To summarize insights from zebrafish MD models and their application in therapeutic screening.

Main Methods:

Review of existing literature on zebrafish myogenesis and MD models.
Analysis of zebrafish larval muscle structure and function.
Examination of therapeutic screening approaches using zebrafish MD models.

Main Results:

Zebrafish possess advantages for modeling human muscle diseases, including ease of genetic manipulation and in vivo imaging.
Zebrafish MD models provide insights into disease pathogenesis and myogenesis.
Larval zebrafish are suitable for high-throughput screening of small molecule inhibitors for MD phenotypes.

Conclusions:

Zebrafish serve as a valuable in vivo system for modeling human skeletal muscle disorders.
Zebrafish MD models contribute to understanding muscle wasting disorders and facilitate therapeutic development.
The zebrafish system is highly relevant for implementing therapeutic screening regimens for MDs.