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High frequency spectral changes induced by single-pulse electric stimulation: Comparison between physiologic and

Mihai Dragos Mălîia¹, Cristian Donos², Andrei Barborica³

¹University Emergency Hospital, Department of Neurology, Bucharest, Romania; Danish Epilepsy Centre, Department of Clinical Neurophysiology, Dianalund, Denmark.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology

|January 30, 2017

Summary

Single-pulse electric stimulation (SPES) reveals brain network interactions. SPES effectively differentiates physiologic and pathologic brain network connectivity in epilepsy patients.

Keywords:

Cortico-cortical connectivity Default mode network Epileptic networks Single-pulse electric stimulation Spectral changes

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Area of Science:

Neuroscience
Systems Neuroscience
Computational Neuroscience

Background:

Understanding functional coupling between brain networks is crucial for diagnosing neurological disorders.
Single-pulse electric stimulation (SPES) offers a potential method for probing these interactions.

Purpose of the Study:

To investigate functional coupling between brain networks using spectral changes induced by SPES.
To differentiate between physiologic and pathologic brain network interactions.

Main Methods:

Analyzed 20 epilepsy patients with depth electrodes, applying SPES to adjacent contacts and recording responses.
Quantified response amplitudes in specific time-periods and frequency ranges (Gamma, Ripples, Fast-Ripples).
Compared stimulation in primary sensory areas (S1-V1) vs. non-S1-V1, seizure onset zone (SOZ) vs. non-SOZ, and default mode network (DMN) vs. non-DMN.

Main Results:

Observed early excitation (10-60ms) and delayed inhibition (60-500ms) following SPES.
Stimulation in S1-V1 showed greater gamma-band inhibition in the DMN.
Stimulation in the SOZ induced greater inhibition in epilepsy-related high frequencies (Ripples and Fast-Ripples).

Conclusions:

Spectral changes induced by SPES can assess both physiologic and pathologic brain network interactions.
SPES is a promising technique for connectivity studies in patients with drug-resistant focal epilepsy.