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Impaired Vascular Function in Sarcoidosis Patients.
I Tuleta1, D Skowasch2, L Biener2
1Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St, D-53105, Bonn, Germany. izabela.tuleta@ukb.uni-bonn.de.
Advances in Experimental Medicine and Biology
|January 30, 2017
Summary
Sarcoidosis patients exhibit impaired vascular function, showing reduced arterial elasticity. This vascular stiffness is worsened by cortisone treatment and advanced pulmonary sarcoidosis with extrapulmonary involvement.
Area of Science:
- Cardiovascular Medicine
- Rheumatology
- Pulmonology
Background:
- Sarcoidosis and atherosclerosis share a chronic inflammatory basis.
- Systemic inflammation in sarcoidosis may impact vascular health.
- Pre-atherosclerotic vascular changes are not well understood in sarcoidosis.
Purpose of the Study:
- To investigate the influence of sarcoidosis on arterial status.
- To identify factors contributing to impaired vascular function in sarcoidosis patients.
- To assess vascular alternations using ultrasound speckle-tracking.
Main Methods:
- Ultrasound-based speckle-tracking analysis of vascular function.
- Inclusion of 72 sarcoidosis patients and 15 matched controls.
- Subgroup analysis based on cortisone therapy, disease stage, and involvement extent.
Main Results:
- Sarcoidosis patients showed significantly decreased circumferential strain, strain rate, and radial displacement.
- Impaired vascular function was more pronounced in patients on cortisone therapy, with advanced pulmonary sarcoidosis (stages III-IV), and extrapulmonary involvement.
- Elevated angiotensin converting enzyme (ACE) or soluble interleukin 2 receptor (sIL-2R) levels did not correlate with vascular parameters.
Conclusions:
- Sarcoidosis is associated with increased arterial stiffness.
- Cortisone therapy and advanced, widespread sarcoidosis contribute to impaired vascular function.
- Early detection and management of vascular changes in sarcoidosis are crucial.
Keywords:
Arterial Elastic PropertiesAtherosclerosisGranulomatous DiseaseInflammationSarcoidosis VasculopathyVascular UltrasoundMore Related Videos
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