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Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action
Hideyuki Sato1, Mizuki Ogino1, Keisuke Yakushiji1
1Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Solid dispersion (SD) significantly enhances ginger extract's (GE) antihypothermic effects by improving the absorption of active compounds like 6-gingerol and 8-gingerol. This approach boosts GE's potential as a nutraceutical.
Area of Science:
- Pharmacology
- Natural Products Chemistry
Background:
- Ginger extract (GE) possesses antihypothermic properties.
- Enhancing the bioavailability of active compounds in GE is crucial for maximizing its therapeutic potential.
Purpose of the Study:
- To improve the antihypothermic action of ginger extract (GE) using a solid dispersion (SD) technique.
- To characterize the physicochemical and pharmacokinetic properties of GE-loaded SD (GE/SD).
Main Methods:
- Preparation and characterization of GE/SD.
- Evaluation of GE/SD's dissolution profile for 6-gingerol (6G) and 8-gingerol (8G).
- Assessment of GE/SD's antihypothermic efficacy in a rat model and pharmacokinetic analysis.
Main Results:
- GE/SD showed significantly improved dissolution rates for 6G (12-fold) and 8G (31-fold) compared to GE.
- GE/SD exhibited 5.0- and 5.8-fold higher relative bioavailability for 6G and 8G, respectively.
- GE/SD effectively inhibited ethanol-induced hypothermia due to enhanced oral absorption.
Conclusions:
- The solid dispersion approach is effective in enhancing the dissolution, bioavailability, and antihypothermic activity of ginger extract.
- SD technology holds promise for improving the nutraceutical applications of ginger and its active constituents.
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