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Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics
Gunchul Shin1, Adrian M Gomez2, Ream Al-Hasani2
1Department of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
Neuron
|January 31, 2017
Summary
Researchers developed a wireless optogenetics system using injectable LEDs and near-field power transfer. This novel technology overcomes limitations of tethered systems, enabling versatile neural circuit research in freely moving animals.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Optogenetics
Background:
- In vivo optogenetics is crucial for studying neural circuits in neuropsychiatric disorders.
- Conventional tethered systems limit experimental flexibility due to physical constraints.
- Existing wireless optogenetics solutions often suffer from bulkiness and limited coverage.
Purpose of the Study:
- To develop a simplified, powerful wireless optogenetics system.
- To overcome the limitations of current tethered and wireless optogenetics hardware.
- To enable complete optical control in diverse behavioral paradigms.
Main Methods:
- Utilized wireless near-field power transfer for untethered operation.
- Developed miniaturized, thin, flexible optoelectronic implants with injectable microscale LEDs.
- Integrated subdermal magnetic coil antennas and an external loop antenna for robust power delivery.
Main Results:
- Demonstrated complete optical control across various wavelengths (UV to red) in behavioral studies.
- Achieved robust wireless power transfer and operation in multiple behavioral setups.
- Created readily mass-producible, user-friendly optogenetic devices.
Conclusions:
- The developed system offers a significant advancement for in vivo optogenetics research.
- This technology provides a versatile and accessible tool for dissecting neural circuits.
- Broad potential applications in neuroscience and the study of brain disorders are anticipated.
