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Medication-associated gastrointestinal tract injury
Michael Vieth1, Elizabeth Montgomery2
1Institute for Pathology, Klinikum Bayreuth, Preuschwitzer Str. 101, 95445, Bayreuth, Germany. vieth.lkpathol@uni-bayreuth.de.
Virchows Archiv : an International Journal of Pathology
|January 31, 2017
Summary
Medication side effects impacting the gastrointestinal tract are common. This review details known and emerging drug-induced gastrointestinal injuries from common medications and newer biologicals.
Area of Science:
- Gastroenterology
- Pharmacology
- Internal Medicine
Background:
- Gastrointestinal (GI) tract injury is a known complication of various medications.
- The increasing use of biologicals introduces new GI side effect profiles.
- Understanding drug-induced GI injury is crucial for patient safety.
Purpose of the Study:
- To review known and emerging medication-associated GI tract injuries.
- To provide a comprehensive list of drugs causing GI injury in clinical practice.
- To highlight the evolving spectrum of GI side effects from biologicals.
Main Methods:
- Literature review of medication-associated GI injuries.
- Compilation of data on established and novel drug-induced GI effects.
- Focus on drugs commonly used in clinical practice.
Main Results:
- Identified a wide range of medications causing GI tract injury.
- Detailed both historical and recently described GI side effects.
- Included both traditional drugs and newer biological agents.
Conclusions:
- Medication-induced GI injury remains a significant clinical concern.
- The emergence of biologicals necessitates ongoing surveillance for novel GI toxicities.
- A comprehensive understanding of drug-GI interactions aids clinical management.
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