Related Experiment Video
Updated: Mar 8, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Juvenile Persistent Acantholytic Dermatosis
Abstract:
An 8 year old boy had recurrent episodes of erythematous papulo - vesicular eruptions on the trunk and extremities persisting for the last 4 years. Repeated biopsies revealed spongiotic acantholysis and pemphigus vulgaris in two separate biopsies. Direct immunofluorescence for fixed antibodies and indirect immunofluorescence for circulating antibodies were negative for IgG, IgA, IgM and C3. This condition is described in patients past 40 years of age. Ours is perhaps the . first child patient with this condition.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Renewal of Skin Epidermal Stem Cells
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

