Related Experiment Video
Updated: Mar 8, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
[Allergen-triggered lichenoid oral mucosa lesions.]
Constanze Olms1, Torsten W Remmerbach
1Poliklinik für Zahnärztliche Prothetik und Werkstoffkunde, Universitätsklinikum Leipzig, Leipzig, Germany.
Abstract:
Allergen-triggered lichenoid oral mucosa lesions may occur both in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Clinically, OLP and OLL are difficult to distinguish from each other. An OLP should be checked by histological examination. Therefore all patients with OLP should be included into a close control interval due to the the potential malignant transformation, whereas in the literature a higher risk of malignancy is attributed to OLL in comparison with OLP. Based on a clinical case, it is demonstrated that an interdisciplinary approach in allergy and mucous diagnosis is necessary to verify the correaltion between a contact allergy to amalgam and the lichenoid mucosal lesions. The subsequent treatment exemplifies the steps of dental therapies with multiple contact allergies to dental materials.
Related Concept Videos
Drug Toxicity: Allergic Reactions
Allergic Reactions
Hypersensitivity Reactions: Immune-Complex Reactions
Allergic Reactions: Anaphylaxis
Allergic Drug Reactions
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

