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Related Experiment Video

Updated: Mar 8, 2026

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

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Published on: August 25, 2022

Fluid Dynamics Appearing during Simulated Microgravity Using Random Positioning Machines.

Simon L Wuest¹, Philip Stern², Ernesto Casartelli²

¹Lucerne University of Applied Sciences and Arts, School of Engineering and Architecture, CC Aerospace Biomedical Science and Technology, Space Biology Group, Hergiswil, Switzerland.

|January 31, 2017

Summary

This summary is machine-generated.

Random Positioning Machines (RPMs) simulate microgravity by rotating samples, but their fluid dynamics are often overlooked. This study reveals that fluid motion and shear stresses within cell culture flasks are significant and depend on RPM speed, impacting experiments.

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Propagation of Dental and Respiratory Cells and Organs in Microgravity

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Published on: May 25, 2021

Area of Science:

Biotechnology
Mechanobiology
Fluid Dynamics

Background:

Random Positioning Machines (RPMs) simulate microgravity by rotating samples, averaging Earth's gravity.
RPMs are increasingly used in non-space research, including scaffold-free spheroid formation.
The fluid dynamics and resulting shear forces within cell culture flasks on RPMs remain largely unexamined.

Purpose of the Study:

To numerically investigate the fluid dynamics inside a cell culture flask on an operating RPM.
To quantify fluid velocity, convection, and shear stress distributions.
To highlight the importance of considering fluid dynamics in RPM-based experiments.

Main Methods:

Numerical simulations were employed to model fluid motion within a cell culture flask.
The study analyzed fluid velocity, shear stress, and their dependence on RPM rotational velocity.

Main Results:

Fluid motion within the flask never reached a steady state.
Fluid velocity reached centimeters per second, influenced by RPM speed.
Shear stresses were highest at flask walls (up to hundreds of mPa) and lower in the bulk volume (around 10 mPa).

Conclusions:

Fluid dynamics on RPMs are significant and cannot be neglected for certain experiments.
Understanding these fluid forces is crucial for interpreting results in microgravity and mechanobiology research.
This study provides essential insights into convection and shear stresses in RPM experiments.