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Area of Science:

  • Pharmacology
  • Analytical Chemistry
  • Sports Science

Background:

  • Selective Androgen Receptor Modulators (SARMs) have been researched for muscle loss conditions like sarcopenia and cachexia.
  • SARMs possess significant muscle- and bone-anabolic properties, leading to potential misuse in sports.
  • Due to misuse, SARMs were added to the World Anti-Doping Agency's (WADA) Prohibited List in 2008.

Purpose of the Study:

  • To review analytical data on SARMs obtained for sports drug testing.
  • To discuss state-of-the-art detection methods for SARMs and their metabolites.
  • To highlight the importance of anti-doping measures against emerging anabolic agents.

Main Methods:

  • Analysis of analytical data from sports drug testing research.
  • Discussion of chromatographic and mass spectrometric techniques.
  • Focus on detecting intact SARMs and their urinary metabolites.

Main Results:

  • Numerous adverse analytical findings for various SARMs have been reported.
  • Chromatography hyphenated to mass spectrometry is the predominant doping control approach.
  • Methods cover a wide range of steroidal and non-steroidal SARMs.

Conclusions:

  • Despite lack of clinical approval, SARMs are misused in sports.
  • Advanced analytical methods are essential for effective doping control.
  • Proactive anti-doping strategies are vital for emerging drugs like SARMs.