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Updated: Mar 8, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
[Molecular mechanisms of pidolate magnesium action and its neurotropic affects]
O A Gromova1, I Yu Torshin2, A G Kalacheva1
1Ivanovo State Medical Academy, Ivanovo, Russia.
Aim:
A complex study of pharmacological properties of magnesium pyroglutamate using the modern methods of chemoinformatics and bioinformatics.
Material And Methods:
Pharmacological properties of magnesium pyroglutamate were studied using chemoinformatic and bioinformatic analyses.
Results:
Neurotropic effects of magnesium pyroglutamate are due to an influence on the synthesis of neuropeptides containing pyroglutamate (orexin, thyroliberin, neurotensin etc) and due to the similarity between pyroglutamate-anion with some neuroactive components (L-theanine, 2-pirrolydinone, piracetam).
Conclusion:
The results of the study suggest neuroprotective, sedative and antidepressive properties of magnesium pyroglutamate which are realized by pyroglutamate-anion in the synergism with magnesium cation.
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