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Updated: Jun 27, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
[Prevention and treatment of COVID-19 based on post-genomic pharmacological analysis: Systematic computer analysis of
I Y Torshin1, O A Gromova1, A G Chuchalin2
1Federal Research Center "Computer Science and Control" of the Russian Academy of Sciences.
Abstract:
The COVID-19 pandemic has highlighted pressing challenges in biomedical research methodology. It has become obvious that the rapid and effective development of treatments for "new" viral infections is impossible without the coordination of interdisciplinary research and in-depth analysis of data obtained within the framework of the post-genomic paradigm. Presents the results of a systematic computer analysis of 290,000 scientific articles on COVID-19, with an emphasis on the results of post-genomic studies of SARS-CoV-2. The futility of the overly simplified approach, which considers only one "most important receptor protein", only one "key virus gene", etc., is shown. It is shown how post-genomic technologies will make it possible to find informative biomarkers of severe coronavirus infection, including those based on complex immune disorders associated with COVID-19.
Insights
The COVID-19 pandemic demands integrated research. Post-genomic analysis of SARS-CoV-2 reveals biomarkers for severe infections, moving beyond single-target approaches.
Area of Science:
- Biomedical Research
- Infectious Diseases
- Genomics
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