[Histologic aspects of the testis in experimental carbon disulfide poisoning]

The histological examination of testes was carried out in white male rats poisoned by the intraperitoneal administration once a week for 6 months of carbon disulphide at different doses of 5, 10, 15, 25 mg/kg body weight. The changes consist in interstitial edema, stasis, congestion, seminiferous tubules basement membrane thickening and spermatogenesis suppression at different stages. There is a direct relation between the intensity of the lesions and the administered dose. The ways of spermatogenesis alteration in the presence of interstitial cells of normal aspect are discussed. The authors believe that carbon disulphide had a direct action both on the central nervous system (hypothalamus--FSH releasing factor) and on testicular structures.