Related Experiment Video
Updated: Mar 8, 2026

Measuring Cardiac Autonomic Nervous System ANS Activity in Toddlers - Resting and Developmental Challenges
Published on: February 25, 2016
Significant Sleep Dysregulation in a Toddler With Developmental Delay
Martin T Stein1, Judith Owens, Myles Abbott
1*Division of Child Development and Community Health, University of California San Diego, Rady Children's Hospital, San Diego, CA; †Alpert Medical School at Brown University, Providence, RI; ‡East Bay Pediatrics (Berkeley, California), Clinical Professor of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA.
This case study examines a 22-month-old with regulatory disorder, developmental delays, and severe sleep problems including night terrors. Interventions like environmental changes and a vibrating mattress were unsuccessful.
Area of Science:
- Pediatrics
- Developmental Psychology
- Sleep Medicine
Background:
- A 22-month-old male presented with a history of developmental delay, hypotonia, and significant sleep disturbances since 6 months of age.
- The child experienced prolonged sleep onset and frequent, severe night awakenings with screaming and thrashing, alongside increased daytime tantrums.
- Previous evaluations identified a regulatory disorder with delays in language and motor development.
Related Concept Videos
REM Sleep Behavior Disorder
RBD is significantly associated with...
Nightmares and Night Terrors
Nightmares...
Oppositional Defiant Disorder
Diagnostic Criteria and...
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...

