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Prenatal exposure to bisphenol A and risk of allergic diseases in early life

Aifen Zhou1,2, Huailong Chang1, Wenqian Huo1

  • 1Key Laboratory of Environment and Health, Ministry of Education &Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Pediatric Research
|February 1, 2017
PubMed

Insights

Prenatal exposure to bisphenol A (BPA) is linked to a higher risk of allergic diseases in infants. This association was particularly noted in female infants born to younger mothers.

Area of Science:

  • Environmental health
  • Pediatric allergy
  • Toxicology

Background:

  • Prenatal bisphenol A (BPA) exposure impacts the immune system, potentially promoting allergies and asthma.
  • Human studies on prenatal BPA exposure and infant allergies are limited.

Purpose of the Study:

  • To investigate the association between prenatal BPA exposure and the risk of allergic diseases in infants.
  • To explore potential sex-specific and age-related differences in this association.

Main Methods:

  • Maternal urine samples (n=412) were collected at delivery in Wuhan, China, to measure BPA concentrations.
  • Infant allergic diseases (eczema, wheeze) were assessed at 6 months via questionnaires.
  • Logistic regression analysis was used to determine the association between BPA levels and allergic disease risk.

Main Results:

  • Mothers of infants with allergies had significantly higher urinary BPA levels compared to controls.
  • Higher creatinine-adjusted maternal urinary BPA concentrations were associated with increased infant allergy risk.
  • This association was significant in female infants (OR=1.36) and infants of mothers younger than 25 (OR=1.90).

Conclusions:

  • Prenatal BPA exposure may increase the risk of allergic diseases in early life.
  • The risk appears more pronounced in female infants and those born to younger mothers.
Abstract

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