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Electronic Alerts for Acute Kidney Injury
Michael Haase1, Andreas Kribben, Walter Zidek
1Department of Research and Science, Medical School Brandenburg Theodor Fontane (MHB); Medical Faculty, Otto-von-Guericke Universität (OvGU), Magdeburg; MVZ Diaverum, Potsdam; MHB; University Clinic for Nephrology and Hypertension, Diabetology and Endocrinology, OVGU Magdeburg; Clinic for Nephrology, Essen University Hospital; Medical Department, Division of Nephrology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin; Clinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Diseases (Medical Clinic II), University Hospital Aachen; Department of Clinical Chemistry and Pathobiochemistry (IKCP), OVGU Magdeburg; Department of Social Medicine & Health Economics (ISMG), OVGU Magdeburg.
Electronic alerts for acute kidney injury (AKI) show improved patient outcomes when treatment recommendations are included. Non-randomized trials suggest these systems enhance care processes and reduce mortality for AKI patients.
Area of Science:
- Nephrology
- Medical Informatics
- Clinical Decision Support
Background:
- Acute kidney injury (AKI) diagnosis and treatment are often delayed, leading to poor outcomes.
- Electronic alert systems aim to provide early warnings for AKI to support physicians.
- Existing evidence on the effectiveness of AKI alert systems is inconsistent.
Purpose of the Study:
- To systematically review the evidence on computer-assisted electronic alert systems for acute kidney injury.
- To evaluate the impact of these systems on process indicators and clinical outcomes.
Main Methods:
- Systematic literature review following PRISMA guidelines.
- Searches conducted in PubMed, Scopus, and Web of Science databases.
- Independent assessment of retrieved studies by two authors.
Main Results:
- 16 studies involving 32,842 patients were analyzed.
- AKI prevalence was 8.5% with 22.8% in-hospital mortality.
- Electronic alerts with treatment recommendations improved diagnostic/therapeutic measures, reduced renal function loss, and lowered mortality in non-randomized trials.
Conclusions:
- Non-randomized controlled trials indicate electronic AKI alerts with treatment recommendations improve care processes and patient outcomes.
- The review's limitations include a small number of randomized trials and diverse study endpoints.
Related Concept Videos
Acute Kidney Injury I: Introduction
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury VI: Nursing Management
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury II: Pathophysiology

