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Updated: Mar 8, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Chromium(II)-catalyzed enantioselective arylation of ketones
Gang Wang1, Shutao Sun2, Ying Mao2
1Shenzhen Research Institute of Shandong University, Shenzhen 518057, China; School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Abstract:
The chromium-catalyzed enantioselective addition of carbo halides to carbonyl compounds is an important transformation in organic synthesis. However, the corresponding catalytic enantioselective arylation of ketones has not been reported to date. Herein, we report the first Cr-catalyzed enantioselective addition of aryl halides to both arylaliphatic and aliphatic ketones with high enantioselectivity in an intramolecular version, providing facile access to enantiopure tetrahydronaphthalen-1-ols and 2,3-dihydro-1H-inden-1-ols containing a tertiary alcohol.
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