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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Cross-bridge Cycle01:26

Cross-bridge Cycle

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As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Related Experiment Video

Updated: Mar 8, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

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Ageing with Muscular Disease.

Bente Martinsen1, Pia Dreyer1

  • 1Section of Nursing, Department of Public Health, Faculty of Health, Aarhus University, Aarhus, Denmark.

The Open Nursing Journal
|February 2, 2017
PubMed
Summary

As people with muscular diseases (MD) live longer, they face challenges balancing autonomy with declining physical abilities. Ageing intensifies this struggle, highlighting a need for age-specific rehabilitation to prevent passive lifestyles.

Area of Science:

  • Gerontology
  • Neurology
  • Public Health

Background:

  • Global populations are aging, presenting new public health challenges.
  • Medical and socioeconomic advances increase longevity, extending life for individuals with chronic conditions.
  • Increased life expectancy is not limited to healthy individuals.

Purpose of the Study:

  • To explore the lived experiences of individuals with muscular diseases (MD) as they age.
  • To understand the unique challenges and adaptations associated with aging with MD.

Main Methods:

  • A comprehensive literature review was performed using Garrard's Matrix Method.
  • An integrative approach was adopted to include studies with diverse methodologies.
  • The review encompassed literature on MD and aging without time restrictions, given increased life expectancy over the past 30 years.
Keywords:
AgeingDisabilityMatrix methodMuscular diseaseReview

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Main Results:

  • Three primary themes emerged: 'Slowing down early,' 'Accepting lifelong deterioration,' and 'Striving for normality.'
  • Individuals with MD experience a continuous tension between maintaining autonomy and coping with progressive physical decline.
  • The physical challenges of aging with MD can overlap with the cessation of rehabilitation services.

Conclusions:

  • Aging exacerbates the conflict between the desire for autonomy/normality and the reality of diminishing physical capacity in individuals with MD.
  • A lack of age-specific rehabilitation services places individuals with MD at risk of reduced quality of life and passivity.
  • There is a critical need for tailored support and rehabilitation programs for the aging population with muscular diseases.