Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.4K

Association of CAA and TATC Insertion/Deletion Genetic Polymorphisms in RTN4 3'-UTR with Hepatocellular Carcinoma

NaNa Wang1, KeYu Chen2, Jia Xu1

  • 1School of Medical Laboratory Science, Chengdu Medical College, Chengdu, 610500, China.

Pathology Oncology Research : POR
|February 2, 2017
PubMed

Insights

Genetic variations in the Reticulon 4 (RTN4) gene, specifically CAA and TATC polymorphisms, are linked to an increased risk of Hepatocellular Carcinoma (HCC). These RTN4 polymorphisms may play a role in HCC development.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Reticulon 4 (RTN4) is a multifunctional gene involved in tumor suppression, apoptosis, vascular remodeling, and axonal regeneration.
  • RTN4 3′-untranslated region (UTR) polymorphisms, specifically CAA and TATC insertion/deletion variants, have been associated with cervical squamous cell carcinoma (CSCC), uterine leiomyomas (UL), and non-small cell lung cancer (NSCLC).

Purpose of the Study:

  • To investigate the association between RTN4 CAA and TATC insertion/deletion polymorphisms and the risk of Hepatocellular Carcinoma (HCC).

Main Methods:

  • Genotyping of RTN4 CAA/TATC insertion/deletion polymorphisms was performed using polymerase chain reaction (PCR) assay.
  • A case-control study was conducted with 284 HCC patients and 484 healthy control subjects from the Chinese Han population.

Main Results:

  • The ID/DD genotypes of the RTN4 CAA polymorphism were significantly associated with an increased risk of HCC compared to the II genotype (ID vs. II: OR=1.50; DD vs. II: OR=2.00).
  • The D allele frequency of the CAA polymorphism was significantly related to an increased HCC risk (D vs. I: OR=1.39).
  • The ID genotype of the TATC polymorphism was significantly associated with an increased HCC risk compared to the DD genotype (ID vs. DD: OR=1.70).

Conclusions:

  • RTN4 CAA and TATC polymorphisms are associated with an increased risk of Hepatocellular Carcinoma (HCC) development.
  • These findings suggest that RTN4 polymorphisms may be potential genetic risk factors for HCC in the Chinese Han population.
Keywords:
Hepatocellular carcinomaNogoPolymorphismsRTN4

More Related Videos

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

11.5K
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.5K

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
60
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
7.4K
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase01:27

Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
51
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
158.7K
Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
21.1K