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Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer

Linbo Gao1,2,3, Fang Yuan1, Guanglu Che4

  • 1Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Journal of Cellular Biochemistry
|March 3, 2019
PubMed
Summary

Genetic variations and epigenetic changes in the Kelch-like ECH-associated protein 1 (KEAP1) gene influence colorectal cancer (CRC) risk. KEAP1 promoter hypermethylation leads to decreased KEAP1 expression, impacting the KEAP1-NRF2 pathway and CRC susceptibility.

Keywords:
Kelch-like ECH-associated protein 1colorectal cancerepigeneticsnuclear factor erythroid 2 like 2polymorphism

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