Related Experiment Video
Updated: Mar 8, 2026
06:34
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
10.5K
Prevailence of Patch Test Positivity with Some Bases.
Indian Journal of Dermatology, Venereology and Leprology
|February 2, 2017
Summary
Propylene glycol is a common base for patch tests but frequently causes false positives in contact dermatitis patients. Water is recommended as a base in tropical regions, with controls for other bases.
Area of Science:
- Dermatology
- Allergology
- Chemical Safety
Background:
- Patch testing is crucial for diagnosing contact dermatitis.
- The choice of vehicle or base for antigens can influence test results.
- Identifying suitable and safe bases is essential for accurate diagnosis.
Purpose of the Study:
- To assess the efficacy and safety of various chemical bases used in patch testing for contact dermatitis.
- To determine which bases elicit the most reliable and specific reactions.
Main Methods:
- Patch tests were conducted on patients with diagnosed contact dermatitis.
- Various chemical agents, including propylene glycol, polyethylene glycol 200, paraffin mixtures, petrolatum, and glycerol, were used as bases for antigens.
- Reactions were evaluated based on intensity (e.g., +, 2+).
Main Results:
- Propylene glycol showed a high rate of positive reactions (50%), with 24% being significant (2+ or more).
- Polyethylene glycol 200 and paraffin mixtures also elicited notable positive reactions.
- Petrolatum and glycerol demonstrated lower reactivity, suggesting better specificity.
Conclusions:
- Propylene glycol is a frequent cause of false-positive results in patch testing for contact dermatitis.
- Water is recommended as a preferred base for antigens, especially in tropical climates.
- When using other bases, including a control test is crucial to differentiate true allergic reactions from irritant or non-specific responses.
More Related Videos
06:31Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
Published on: October 3, 2019
9.3K
07:10Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
Published on: April 21, 2019
17.0K
Related Concept Videos
01:26Pulmonary Tuberculosis IV
592
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
592
01:31Pulmonary Tuberculosis III
1.2K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.2K
01:08Prevalence and Incidence
2.2K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
2.2K
01:18Patch Clamp
7.0K
Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
7.0K
01:13Sensitivity, Specificity, and Predicted Value
1.6K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
Sensitivity is the...
1.6K
01:30Drug Toxicity: Allergic Reactions
80
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
80