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Captopril Induced Pemphigus Vulgaris.
Indian Journal of Dermatology, Venereology and Leprology
|February 2, 2017
Summary
Captopril, a medication for high blood pressure, may cause pemphigus vulgaris, a serious skin condition. Drug withdrawal led to rapid skin lesion healing, suggesting captopril as the cause.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Essential hypertension management often involves angiotensin-converting enzyme (ACE) inhibitors like captopril.
- Drug-induced dermatological reactions can range from mild rashes to severe blistering disorders.
Observation:
- A 51-year-old male developed flaccid vesicles and bullae on the scalp, face, trunk, and oral mucosa.
- These symptoms appeared 22 days after initiating captopril (200 mg daily) for hypertension.
Findings:
- Clinical and histopathological findings were consistent with pemphigus vulgaris.
- Skin lesions completely resolved within 15 days of discontinuing captopril.
- No recurrence was observed during a one-year follow-up period.
Implications:
- Captopril should be considered a potential cause of drug-induced pemphigus vulgaris.
- Prompt drug withdrawal is crucial for managing this adverse reaction.
- This case highlights the importance of considering medication history in diagnosing autoimmune blistering diseases.
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