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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
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Computational imaging reveals shape differences between normal and malignant prostates on MRI.

Mirabela Rusu1, Andrei S Purysko2, Sadhna Verma3

  • 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, 44106, USA.

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|February 2, 2017
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Summary
This summary is machine-generated.

Prostate cancer detection using MRI reveals distinct shape differences. Central gland hypertrophy was observed in biopsy-negative men, while apex shape variations were noted in cancer-positive patients compared to those with rectal cancer.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Urology

Background:

  • Prostate cancer diagnosis relies on various methods, including biopsy and MRI.
  • Understanding prostate and central gland shape variations can aid in diagnosis.
  • Distinguishing between prostate cancer and other pelvic conditions using imaging is crucial.

Purpose of the Study:

  • To characterize shape differences in the prostate and central gland between men with and without prostate cancer.
  • To identify specific anatomical regions exhibiting shape variations associated with prostate cancer.
  • To compare prostate shape in cancer-positive men versus those with negative biopsies or non-prostate malignancies.

Main Methods:

  • T2w MRI scans from 70 men across three institutions were analyzed.
  • Prostate and central gland boundaries were delineated by expert raters.
  • Statistical shape atlases were constructed for cancer-positive (PCa+), biopsy-negative (Bx-), and cancer-negative/other malignancy (Cl-) groups.
  • Per-voxel statistical tests were employed to identify significant shape differences.

Main Results:

  • Central gland hypertrophy was identified in the Bx- subpopulation, showing significant volume and posterior shape differences compared to the PCa+ group.
  • Significant prostate shape differences were observed at the apex when comparing the Cl- and PCa+ groups.
  • These findings highlight distinct morphological patterns associated with different prostate conditions.

Conclusions:

  • Prostate and central gland shape analysis using T2w MRI can reveal differences between men with and without prostate cancer.
  • Central gland hypertrophy is associated with biopsy-negative findings, while apex shape variations may indicate prostate cancer.
  • These shape characteristics could potentially serve as imaging biomarkers for prostate cancer detection and differentiation.