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Perdiem causes esophageal impaction and bezoars.
1Department of Medicine, St. Thomas Hospital, Nashville, TN 37202.
Southern Medical Journal
|November 1, 1989
Summary
Perdiem, a bulk laxative, can cause esophageal impaction and gastric bezoars due to its granule formulation. Bougienage is an effective treatment for these serious complications.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Bulk laxatives, primarily psyllium-based like Perdiem, are commonly used for constipation.
- The granular formulation of Perdiem presents unique physical properties that may lead to adverse events.
Observation:
- Three cases of esophageal impaction were reported following Perdiem ingestion.
- One patient also developed a gastric bezoar, a mass of undigested material.
Findings:
- Perdiem granules can adhere, leading to obstruction in the esophagus and stomach.
- Bougienage provided effective relief for esophageal impactions, contrasting with the typically favored endoscopic manipulation.
Implications:
- Healthcare providers and patients must be aware of the risk of esophageal impaction and gastric bezoars with Perdiem.
- Alternative or modified administration methods for bulk laxatives may be warranted to mitigate these risks.
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