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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Drug Toxicity: Allergic Reactions01:30

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Behcet's disease.

Jagdish R Nair1, Robert J Moots2

  • 1National Behcet's Syndrome Centre of Excellence, Aintree University Hospital, Liverpool, UK.

Clinical Medicine (London, England)
|February 3, 2017
PubMed
Summary
This summary is machine-generated.

Behçet's disease is a chronic vasculitis affecting multiple organs. Research into its genetic and environmental causes is ongoing, with treatments ranging from symptomatic relief to immunosuppressive drugs.

Keywords:
Behcet's diseasebiological drugsdisease-modifying drugsimmunosuppressionvasculitis

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Area of Science:

  • Immunology
  • Rheumatology
  • Genetics

Background:

  • Behçet's disease (BD) is a chronic, relapsing vasculitis with unknown causes.
  • It can affect multiple organ systems, leading to significant morbidity and mortality.
  • BD occurs worldwide and is historically known as the 'silk road' disease.

Purpose of the Study:

  • To explore the aetiopathological mechanisms of Behçet's disease.
  • To understand the genetic and environmental factors contributing to BD.
  • To review current and emerging treatment options for BD.

Main Methods:

  • Genome-wide association studies (GWAS) to identify genetic associations.
  • Analysis of environmental influences on disease development.
  • Review of existing literature on treatment strategies.

Main Results:

  • Genome-wide studies reveal associations with human leukocyte antigen (HLA) and non-HLA genes.
  • Evidence suggests a role for both genetic and environmental factors in BD aetiopathogenesis.
  • The autoimmune and auto-inflammatory nature of BD is indicated.

Conclusions:

  • The exact causes of Behçet's disease remain unclear.
  • Genetic and environmental factors likely contribute to its development.
  • Treatment options are diverse, ranging from symptomatic care to advanced immunosuppressive therapies.