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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Related Experiment Video

Updated: Mar 8, 2026

Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
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Artificial Antigen-Presenting Cells for Immunotherapies.

Alyssa L Siefert1, Tarek M Fahmy1, Dongin Kim2,3

  • 1Department of Biomedical Engineering, Yale University, 55 Prospect St., New Haven, CT, 06520, USA.

Methods in Molecular Biology (Clifton, N.J.)
|February 3, 2017
PubMed
Summary

Artificial antigen-presenting cells (aAPCs) offer an acellular alternative for adoptive immunotherapy. This study details a polymeric microparticle aAPC platform that effectively stimulates T cell activation and proliferation.

Keywords:
ImmunotherapyMicroparticlePLGAParacrine deliveryPolymeraAPC

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Cell Therapy

Background:

  • Biologically based adoptive immunotherapy faces limitations.
  • Artificial antigen-presenting cells (aAPCs) present a promising acellular alternative.
  • Designing aAPCs requires careful consideration of material properties and signaling.

Purpose of the Study:

  • To outline methods for formulating and characterizing a comprehensive polymeric microparticle aAPC platform.
  • To demonstrate the efficacy of these aAPCs in stimulating T cell responses.
  • To establish a reproducible method for large-scale aAPC fabrication.

Main Methods:

  • Fabrication of polymeric microparticle aAPCs with controlled parameters (material, diameter).
  • Characterization of aAPC platform for reproducibility and scalability.
  • Assessment of T cell activation and proliferation stimulated by aAPCs.

Main Results:

  • Reproducible fabrication of polymeric microparticle aAPCs in large quantities.
  • Efficient stimulation of antigen-specific T cell activation.
  • Effective induction of T cell proliferation via paracrine cytokine signals and surface protein engagement.

Conclusions:

  • Polymeric microparticle aAPCs provide a versatile and scalable platform for immunotherapy.
  • These aAPCs can overcome limitations of traditional adoptive immunotherapy approaches.
  • The developed platform shows potential for enhancing T cell-based therapies.