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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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UniProt Protein Knowledgebase.

Sangya Pundir1, Maria J Martin2, Claire O'Donovan2

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. spundir@ebi.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)
|February 3, 2017
PubMed
Summary
This summary is machine-generated.

The Universal Protein Resource (UniProt) provides comprehensive protein data and annotation. This resource aids researchers in accessing and utilizing vital protein information for various scientific applications.

Keywords:
Protein dataProtein toolsUniProt

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Area of Science:

  • Bioinformatics
  • Proteomics
  • Molecular Biology

Background:

  • The Universal Protein Resource (UniProt) is a key global initiative.
  • It is a collaborative effort between EMBL-EBI, SIB, and PIR.
  • Over 100 experts contribute to data curation and development.

Purpose of the Study:

  • To introduce the functionality and data within UniProt.
  • To illustrate practical use cases for UniProt.
  • To guide users on accessing and utilizing protein data.

Main Methods:

  • Expert curation of protein sequence and annotation data.
  • Development of robust software tools for data access.
  • Providing comprehensive documentation and support.

Main Results:

  • UniProt offers a vast, freely accessible repository of protein information.
  • The resource supports diverse research needs through its extensive dataset.
  • User-friendly access methods facilitate efficient data retrieval.

Conclusions:

  • UniProt is an indispensable resource for the scientific community.
  • Its collaborative nature ensures high-quality, up-to-date protein data.
  • Researchers can effectively leverage UniProt for diverse biological investigations.