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Related Concept Videos

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Related Experiment Video

Updated: Mar 8, 2026

Electroporation of the Hindbrain to Trace Axonal Trajectories and Synaptic Targets in the Chick Embryo
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Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons.

Zoé Christenson Wick1, Caara H Leintz1, Casey Xamonthiene1

  • 1Neuroscience Department, University of Minnesota, Minneapolis.

Journal of Neuroscience Research
|February 3, 2017
PubMed
Summary

Commissural inhibition from parvalbumin (PV) interneurons suppresses seizures in temporal lobe epilepsy (TLE). These PV interneurons sprout projections in the TLE hippocampus, enhancing contralateral inhibition.

Keywords:
FluorogoldRRID: AB_2631173axonal sproutingcommissuralepilepsyhippocampusinhibitory interneuronparvalbumin

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Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Cellular Neuroscience

Background:

  • Optogenetic stimulation of parvalbumin (PV) interneurons can suppress seizures in temporal lobe epilepsy (TLE).
  • Seizure suppression occurred regardless of stimulation side, suggesting potential commissural inhibition.
  • Commissural projections of hippocampal PV interneurons in TLE are not well understood.

Purpose of the Study:

  • To investigate the presence and plasticity of commissural PV interneuron projections in a mouse model of TLE.
  • To determine if TLE network reorganization affects contralateral hippocampal inhibition.

Main Methods:

  • Used retrograde labeling and viral vector technology in the intrahippocampal kainate mouse model of TLE.
  • Examined both sexes to assess commissural projections in healthy controls and TLE models at 2 weeks and 6 months post-kainate injection.
  • Utilized viral green fluorescent protein expression to visualize PV neuron projections.

Main Results:

  • Healthy controls have commissurally projecting hippocampal PV interneurons.
  • A non-significant decrease in contralateral PV interneurons was observed at 2 weeks post-kainate.
  • A significant increase in contralateral PV interneurons was observed at 6 months post-kainate, indicating axonal sprouting.
  • Sprouting of commissural PV projections was confirmed in the dentate gyrus of the TLE hippocampus.

Conclusions:

  • Hippocampal PV interneurons form direct inhibitory connections to the contralateral hippocampus.
  • These commissural connections undergo significant axonal sprouting in a mouse model of TLE.
  • This sprouting suggests a compensatory mechanism for altered network activity in TLE.