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Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends.

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Ionic liquids (ILs) offer versatile applications for extracting and purifying bioactive compounds. This review compiles IL-based processes, highlighting their effectiveness and future potential in separation science.

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Area of Science:

  • Green Chemistry
  • Separation Science
  • Biotechnology

Background:

  • Ionic liquids (ILs) are tunable solvents with unique properties for extraction and separation.
  • Bioactive compound extraction is crucial for pharmaceuticals, nutraceuticals, and biofuels.
  • Traditional methods often face limitations in efficiency and environmental impact.

Purpose of the Study:

  • To critically review and compile the main results of IL-based processes for bioactive compound extraction and purification.
  • To compare different IL-based separation techniques.
  • To identify key accomplishments, challenges, and future directions in the field.

Main Methods:

  • Review of literature on IL applications in extraction and separation.
  • Analysis of ILs as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants.
  • Examination of IL-based solid-liquid extractions, liquid-liquid extractions, modified materials, and crystallization.

Main Results:

  • ILs demonstrate significant potential in extracting diverse bioactive compounds, including lipids, proteins, and pharmaceuticals.
  • IL-based processes show promise for improved separation performance compared to conventional methods.
  • ILs can be integrated into various separation strategies, such as supported materials and crystallization.

Conclusions:

  • Ionic liquids are highly effective for a wide range of bioactive compound separations.
  • Further research is needed to address current limitations and optimize IL-based separation processes.
  • The field requires focused efforts to overcome challenges and fully realize the potential of ILs in separation science.