Related Experiment Video

Updated: Mar 8, 2026

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

12.1K

Native T1 value in the remote myocardium is independently associated with left ventricular dysfunction in patients

Shiro Nakamori1, Javid Alakbarli1, Steven Bellm1

  • 1Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

Journal of Magnetic Resonance Imaging : JMRI
|February 3, 2017
PubMed

Insights

Elevated remote myocardium native T1 in patients with chronic myocardial infarction (MI) is linked to left ventricular (LV) systolic dysfunction. This finding suggests diffuse myocardial fibrosis plays a role in post-MI LV dysfunction.

Area of Science:

  • Cardiovascular Imaging
  • Cardiac Magnetic Resonance (CMR)
  • Myocardial Fibrosis

Background:

  • Chronic myocardial infarction (MI) can lead to impaired left ventricular (LV) systolic function.
  • Assessing remote myocardium characteristics is crucial for understanding post-MI outcomes.
  • Native T1 mapping offers insights into diffuse myocardial tissue properties.

Purpose of the Study:

  • To compare remote myocardium native T1 values in patients with chronic MI versus controls.
  • To investigate the relationship between infarct size, remote myocardium native T1, and LV systolic dysfunction.
  • To determine if remote myocardium native T1 predicts LV systolic dysfunction after MI.

Main Methods:

  • Cardiac MRI at 1.5T was performed on 41 chronic MI patients and 15 controls.
  • Native T1 mapping and late gadolinium enhancement (LGE) imaging were utilized.
  • Cine MR assessed LV function and mass.

Main Results:

  • Remote myocardium native T1 was significantly elevated in MI patients compared to controls (P < 0.05).
  • Native T1 moderately correlated with LV volume, mass index, and ejection fraction (all P < 0.05).
  • Native T1 was independently associated with reduced LV ejection fraction (β = -0.34, P = 0.03).

Conclusions:

  • Remote myocardium native T1 is independently associated with the severity of LV systolic dysfunction in chronic MI.
  • Diffuse myocardial fibrosis in the remote myocardium may contribute to post-MI LV dysfunction.
  • Native T1 mapping is a valuable tool for assessing myocardial tissue changes after MI.
Abstract

Keywords:
diffuse myocardial fibrosisleft ventricular dysfunctionmyocardial infarctionnative T1 map

More Related Videos

A Microscopic 2,3,5-Triphenyltetrazolium Chloride Assay for Accurate and Reliable Analysis of Myocardial Injury11:17

A Microscopic 2,3,5-Triphenyltetrazolium Chloride Assay for Accurate and Reliable Analysis of Myocardial Injury

Published on: November 28, 2025

381
Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

28.9K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.0K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
522
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
394
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
355