Related Experiment Video
Updated: Mar 8, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
Poor medication adherence in clinical trials: consequences and solutions
Alasdair Breckenridge1, Jeffrey K Aronson2, Terrence F Blaschke3
1Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, UK.
Poor adherence to medicines in clinical trials can negatively impact trial results and estimations of drug benefits and risks. This article discusses these consequences and proposes solutions to improve patient adherence.
Area of Science:
- Clinical research methodology
- Pharmacovigilance
- Patient compliance studies
Background:
- Patient adherence to medication is crucial for the validity of clinical trials.
- Non-adherence can significantly skew results regarding drug efficacy and safety.
- Undermining trial value leads to unreliable data on benefits and risks.
Purpose of the Study:
- To highlight the negative consequences of poor medicine adherence in clinical trials.
- To discuss strategies for improving patient adherence in research settings.
Main Methods:
- Literature review on adherence challenges in clinical trials.
- Analysis of the impact of non-adherence on trial outcomes.
- Exploration of interventions to enhance patient compliance.
Main Results:
- Poor adherence compromises the accuracy of benefit-risk assessments.
- It can lead to incorrect conclusions about a drug's performance.
- Methods to improve adherence are essential for trial integrity.
Conclusions:
- Addressing poor medicine adherence is vital for maintaining the integrity and value of clinical trials.
- Implementing targeted strategies can improve patient compliance and ensure reliable trial data.
More Related Videos
09:42Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
Published on: November 8, 2013
04:53A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Related Concept Videos
Drug Therapy
Antianxiety Medications
Clinical Trials
There are four phases in a clinical trial. A phase one...
Drug Dosing: Geriatric Patients
Therapeutic Drug Monitoring: Affecting Factors
Bioavailability Study Design: Healthy Subjects Versus Patients
Drug Toxicity: Risk factors