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Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina
Tolga Han Efe1, Burak Açar2, Ahmet Göktuğ Ertem2
1Dışkapı Yıldırım Beyazıt Training and Research Hospital, Cardiology Clinic, Ankara, Turkey.
Insights
Lower serum irisin levels are linked to increased coronary artery severity in stable coronary artery disease (CAD) patients. This finding suggests irisin may predict disease progression in individuals with CAD.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Metabolomics
Background:
- Irisin, a myokine, is implicated in adipose tissue metabolism.
- Stable coronary artery disease (CAD) affects a significant population worldwide.
- Understanding novel biomarkers for CAD severity is crucial for patient management.
Purpose of the Study:
- To investigate the association between serum irisin levels and coronary artery severity.
- To determine if irisin can serve as a predictor for CAD severity.
Main Methods:
- Study included 63 stable CAD patients and 26 controls.
- CAD patients were stratified by SYNTAX score (high ≥23 vs. low <23).
- Serum irisin was quantified using an enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Patients with high SYNTAX scores had significantly lower serum irisin levels (127.91±55.38 ng/mL).
- Lower SYNTAX score group (224.69±92.99 ng/mL) and control group (299.54±123.20 ng/mL) showed higher irisin levels.
- Significant differences in irisin levels were observed across all groups (p<0.001).
Conclusions:
- Serum irisin level is an independent predictor of coronary artery severity in stable CAD.
- Lower irisin may indicate more severe coronary artery disease.
- Irisin warrants further investigation as a potential biomarker in cardiovascular disease.
Background And Objectives:
The recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD).
Subjects And Methods:
Sixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD and twenty-six patients with normal coronary artery (NCA) were enrolled in the study. Stable CAD patients were divided into two groups as high synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score (≥23) and lower SYNTAX score (<23). Serum irisin level measurement was carried out using human irisin colorimetric enzyme-linked immunosorbent assay (ELISA) commercial kit (AG-45A-0046EK-KI01, Adipogen, San Diego, CA, USA) as recommended by the manufacturer's protocol.
Results:
The patients with stable CAD with a higher SYNTAX score (score ≥23) had significantly lower serum irisin levels (127.91±55.38 ng/mL), as compared the patients with a low SYNTAX score (score <23) (224.69±92.99 ng/mL) and control group (299.54±123.20 ng/mL). Irisin levels showed significant differences between all groups (p<0.001).
Conclusion:
Serum irisin level is an independent predictor of coronary artery severity in patients with stable CAD.
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