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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Related Experiment Video

Updated: Mar 8, 2026

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
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Eosinophilic endomyocardial disease.

Victor Y Liu1, Raymundo A Quintana-Quezada2, L Maximilian Buja2

  • 1Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1.150, Houston, TXs 77030, United States..

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|February 4, 2017
PubMed
Summary

Eosinophilic granulomatosis with polyangiitis, a rare vasculitis, can affect the heart, presenting as a left ventricular thrombus. Early diagnosis is crucial due to its multi-systemic nature and resemblance to common conditions.

Keywords:
BiopsyCardiac PathologyEosinophiliaVasculitis

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Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
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Area of Science:

  • Cardiology
  • Rheumatology
  • Pathology

Background:

  • Eosinophilic granulomatosis with polyangiitis (EGPA) is the least common antineutrophil cytoplasmic antibody-associated vasculitis.
  • EGPA can manifest with diverse symptoms, complicating its diagnosis.
  • Cardiac involvement in EGPA, though rare, can lead to severe complications.

Observation:

  • A 58-year-old woman with a history of asthma presented with a left ventricular apical thrombus.
  • Diagnostic workup included cardiac catheterization and endomyocardial biopsy.
  • Biopsy results were consistent with eosinophilic endomyocardial disease.

Findings:

  • The patient's presentation mimicked other cardiac conditions.
  • Eosinophilic endomyocardial disease was confirmed via biopsy.
  • EGPA's multi-organ involvement and overlapping symptoms present diagnostic challenges.

Implications:

  • Highlights the importance of considering EGPA in patients with unexplained cardiac findings, especially those with a history of asthma or eosinophilia.
  • Emphasizes the need for thorough diagnostic evaluation to differentiate EGPA from more common conditions.
  • Underscores the potential for cardiac complications in EGPA, necessitating timely recognition and management.