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Updated: Jan 20, 2026
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat
1Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY 14652-3615.
Abstract:
1. The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. 2. DGBA (5 mM) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of less than 3 min. 3. 14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 h following oral administration at 200 or 2000 mg/kg. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. No unchanged DGBA or DGBE was detected in rat urine at either dose level. 4. No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats.
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