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Legionnaire's Disease and Influenza

Eleni E Magira1, Sryros Zakynthinos2

  • 11st Department of Critical Care Medicine, Evangelismos General Hospital, National and Kapodistrian University of Athens, 45-47 Ispilandou Street, Athens 10675, Greece.

Infectious Disease Clinics of North America
|February 5, 2017
PubMed

Insights

Coinfection with Legionella bacteria and influenza viruses can lead to severe pneumonia. Understanding these complex interactions is key to preventing potentially fatal secondary bacterial infections after influenza.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Virology

Background:

  • Legionella pneumophila and influenza viruses (A and B) can cause community-acquired pneumonia.
  • Coinfection presents complex interactions between pathogens and the host, complicating understanding of secondary bacterial infections during influenza.
  • Dual infections can impair viral control and delay viral clearance.

Purpose of the Study:

  • To explore the copathogenesis between influenza and Legionella.
  • To understand the emergence of secondary bacterial infections during influenza.
  • To highlight the impact of dual infections on viral clearance.

Main Methods:

  • Literature review on influenza-Legionella coinfections.
  • Analysis of host-pathogen interactions in dual infections.
  • Review of clinical outcomes and prognostic factors.

Main Results:

  • Coinfection can lead to severe pneumonia with respiratory failure.
  • Secondary Legionella infection following influenza has a potentially fatal prognosis.
  • Dual infections negatively impact viral control and clearance.

Conclusions:

  • Effective influenza vaccines and antiviral therapies are crucial.
  • Interventions can increase resistance to influenza and reduce its prevalence.
  • Preventing influenza may interrupt secondary bacterial infections.
Keywords:
CoinfectionHostImmunopathogenesisInfluenzaLegionellosisSecondary infection

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