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Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

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Bioprinting Using Mechanically Robust Core-Shell Cell-Laden Hydrogel Strands.

Pritesh Mistry¹, Ahmed Aied¹, Morgan Alexander²

¹Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.

Macromolecular Bioscience

|February 5, 2017

Summary

This summary is machine-generated.

Researchers developed a novel core-shell bioprinting method. This technique creates functional human tissues by combining robust mechanical properties with excellent cell viability and function.

Keywords:

bioprinting hydrogels mechanical properties tissue engineering

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Published on: October 13, 2021

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Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

The choice of strand material in extrusion-based bioprinting critically influences cellular microenvironments and construct mechanics.
A significant challenge in bioprinting is achieving constructs with both superior biological and mechanical characteristics.

Purpose of the Study:

To develop a novel bioprinting strategy addressing the limitations of current methods.
To create cell-laden constructs with combined optimal biological and mechanical properties.

Main Methods:

Development of a core-shell bioprinting technique using cell-laden strands.
The core-shell strands feature a mechanically strong shell and an extracellular matrix-like core.
Assessment of cell viability and function within the bioprinted constructs during cultivation.

Main Results:

Cells encapsulated within the core-shell strands exhibited high viability.
Embedded cells maintained tissue-like functions throughout the cultivation period.
The developed method successfully fabricated constructs with desirable biochemical and biomechanical properties.

Conclusions:

The core-shell bioprinting method offers a new approach for tissue fabrication.
This strategy enables the creation of functional human tissues and organs.
The combination of robust mechanics and biological functionality is achievable with this technique.