Related Experiment Video
Updated: Mar 8, 2026

07:57
Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
Published on: December 8, 2011
34.6K
Oral yeast colonization throughout pregnancy.
R Rio1, L Simões-Silva, S Garro
1Faculdade de Medicina, Dentária da Universidade do Porto, Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal, bmaia@fmd.up.pt.
Medicina Oral, Patologia Oral Y Cirugia Bucal
|February 5, 2017
Summary
Pregnancy may increase oral yeast colonization, potentially due to a more acidic oral environment. This study tracked yeast in pregnant and non-pregnant women over six months.
Area of Science:
- Microbiology
- Oral Health
- Maternal Health
Background:
- Emerging evidence suggests a link between the maternal oral microbiome and the placenta.
- Pregnancy involves significant physiological and hormonal changes affecting the oral environment.
- Limited research has explored oral microbiota shifts during pregnancy.
Purpose of the Study:
- To investigate oral yeast colonization throughout pregnancy.
- To compare oral yeast prevalence in pregnant versus non-pregnant women.
Main Methods:
- Saliva samples from 30 pregnant and 30 non-pregnant women were analyzed over six months.
- Demographic data, oral examinations, saliva flow, and pH were recorded.
- Oral yeast colonization was assessed longitudinally.
Main Results:
- Saliva pH was lower in pregnant women compared to non-pregnant women.
- Oral yeast prevalence was higher in pregnant women during both trimesters, though not statistically significant.
- Yeast load (Log10CFU/mL) increased from the first to the third trimester in pregnant women.
Conclusions:
- Pregnancy appears to promote oral yeast growth.
- An acidic oral environment during pregnancy may contribute to increased yeast colonization.
Related Concept Videos
Yeast Signaling
18.3K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
18.3K
Oogenesis
70.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
70.8K
Development of Immunocompetence
1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Diabetes Mellitus: Type 2 and Gestational
5.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.3K
Teratogenicity
4.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
Ovarian Cycle
4.8K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
4.8K

