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Updated: Mar 8, 2026

CRISPR-Mediated Reorganization of Chromatin Loop Structure
Published on: September 14, 2018
Epigenetic interplay at the β-globin locus
Wei Shern Lee1, Bradley McColl1, Jovana Maksimovic2
1Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, Vic. 3052 Melbourne, Australia.
Abstract:
During development, the α- and β-globin genes exhibit a highly conserved pattern of expression, giving rise to several developmental stage-specific hemoglobin variants. Networks of regulatory proteins interact with epigenetic complexes to regulate DNA accessibility and histone modifications, thereby determining appropriate patterns of globin gene expression. In this review, we focus on recent advances in the understanding of the molecular mechanisms that underpin globin gene expression, focusing on multi-subunit regulatory complexes that bind to specific regions of DNA to orchestrate globin gene transcription throughout development.
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