Related Experiment Video

Updated: Mar 8, 2026

A Nonsequencing Approach for the Rapid Detection of RNA Editing
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A Nonsequencing Approach for the Rapid Detection of RNA Editing

Published on: April 21, 2022

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Identification of Diverse Adenosine-to-Inosine RNA Editing Subtypes in Colorectal Cancer

Si-Hyun Lee1, Hwang-Phill Kim1,2, Jun-Kyu Kang1,2

  • 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University College of Medicine, Seoul, Korea.

Cancer Research and Treatment
|February 7, 2017
PubMed
Abstract

Insights

This study identified novel RNA editing patterns in colorectal cancer (CRC), revealing potential biomarkers for patient identification. Specific gene editing alterations were observed, distinguishing cancer from normal tissues.

Area of Science:

  • Molecular Biology
  • Genomics
  • Cancer Research

Background:

  • RNA editing diversifies proteins without altering DNA.
  • Adenosine-to-inosine (A-to-I) RNA editing is rare in colorectal cancer (CRC).

Purpose of the Study:

  • To identify diverse RNA editing patterns in human colorectal cancer (CRC).
  • To investigate nonsynonymous RNA editing in CRC.
  • To explore RNA editing as potential CRC biomarkers.

Main Methods:

  • Compared transcriptome data from 39 CRC samples and adjacent tissues.
  • Focused on canonical A-to-I RNA edits in coding regions.
  • Analyzed nonsynonymous RNA editing patterns.

Main Results:

  • Identified 10 recurrent nonsynonymous RNA editing candidates in nine genes.
  • Observed both hypo- and hyper-RNA editing patterns in CRC samples.
  • Found increased editing of GLI1 in cancer tissues, while most other genes were hypoedited.

Conclusions:

  • Nonsynonymous RNA editing patterns can distinguish CRC patients.
  • Identified RNA editing events may serve as novel biomarkers for CRC detection.
Keywords:
Adenosine deaminaseColorectal neoplasmsGLI family zinc finger 1RNA editingTranscriptome sequencing

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