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Lymphocyte subsets in human encephalitic and paralytic rabies
B Sriwanthana1, T Hemachudha, D E Griffin
1Science Division, Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok.
Acta Neurologica Scandinavica
|October 1, 1989
Summary
Rabies infection significantly impacts lymphocyte subsets. Natural killer cells (Leu 7) were diminished in most patients, while B cells (Leu 12) were reduced in paralytic rabies cases.
Area of Science:
- Immunology
- Virology
- Neurology
Background:
- Rabies is a severe viral disease affecting the central nervous system.
- Understanding the immune response in rabies is crucial for patient management.
Purpose of the Study:
- To investigate alterations in lymphocyte subsets during encephalitic and paralytic rabies.
- To characterize the immunophenotype of immune cells in rabies patients.
Main Methods:
- Immunocytochemical techniques were employed.
- Mouse monoclonal antibodies were used to identify lymphocyte subsets.
- Analysis included Leu 7 (natural killer cells) and Leu 12 (B cells) markers.
Main Results:
- A significant decrease in natural killer (NK) cells (Leu 7 phenotype) was observed in nearly all patients.
- B cells (Leu 12 marker) showed a reduction in paralytic rabies patients compared to encephalitic cases.
Conclusions:
- Rabies infection leads to notable changes in peripheral blood lymphocyte populations.
- NK cell depletion is a common finding, while B cell reduction may be more specific to paralytic forms of rabies.