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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
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Programmed cell death and the immune system.

Shigekazu Nagata1, Masato Tanaka2

  • 1Laboratory of Biochemistry and Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

Nature Reviews. Immunology
|February 7, 2017
PubMed
Summary
This summary is machine-generated.

Programmed cell death, including apoptosis, is crucial for immune system function. This timeline highlights key discoveries showing its importance in immunity.

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Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • Programmed cell death was first observed in insect development over 50 years ago.
  • A similar process, termed apoptosis, was later identified in humans.
  • Apoptosis plays essential roles in the immune system, with key regulators identified in the 1990s.

Purpose of the Study:

  • To provide a historical overview of programmed cell death research.
  • To highlight pivotal discoveries concerning apoptosis and programmed necrosis in immunity.
  • To emphasize the significance of these cell death pathways in immune system function.

Main Methods:

  • Historical review of scientific literature.
  • Chronological compilation of key research milestones.
  • Focus on discoveries related to apoptosis and programmed necrosis.

Main Results:

  • Identification of programmed cell death in insects and its subsequent renaming to apoptosis in humans.
  • Discovery of apoptosis-regulating molecules and their immune system roles.
  • Recognition of both apoptosis and programmed necrosis as critical immune processes.

Conclusions:

  • Programmed cell death pathways are fundamental to immune system development and function.
  • Apoptosis and programmed necrosis are vital for maintaining immune homeostasis.
  • Continued research into programmed cell death mechanisms is essential for understanding immunity.