Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pigmentation01:19

Pigmentation

4.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.8K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.0K
Epistasis01:39

Epistasis

50.7K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
50.7K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.0K
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

73
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
73
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

80
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
80

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Energy and carbon budgeting of traditional land use change with groundnut based cropping system for environmental quality, resilient soil health and farmers income in eastern Indian Himalayas.

Journal of environmental management·2021
Same author

Plamar Dermatoglyphics in Psorlasis-a Pilot Study.

Indian journal of dermatology, venereology and leprology·2017
Same author

A study of pattern of nonvenereal genital dermatoses of male attending skin OPD at a tertiary care center.

Indian journal of sexually transmitted diseases and AIDS·2015
Same author

A study of rheumatological manifestations of leprosy.

Indian journal of dermatology, venereology and leprology·2007
Same author

Suction blister epidermal grafting versus punch skin grafting in recalcitrant and stable vitiligo.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·1999
Same author

Congenital alopecia universalis.

The Journal of the Association of Physicians of India·1989
Same journal

A decade of trends in patch test allergen sensitisation from a dermatology centre in Southeast Asia.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Patients with congenital ichthyosis show differential activation of IL-23/Th17 pathway among various disease subtypes - A single-centre experience.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Predictors of severity of sequelae in discoid lupus erythematosus: A longitudinal cohort study.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Impact of social media-based follow-up nursing on itch severity and self-care in atopic dermatitis patients: A randomised controlled trial.

Indian journal of dermatology, venereology and leprology·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K

Urticaria Pigmentosa.

P K Saraswat, N N Laha

    Indian Journal of Dermatology, Venereology and Leprology
    |February 7, 2017
    PubMed
    Summary
    This summary is machine-generated.

    A rare case of urticaria pigmentosa presented with bullous lesions in a two-year-old child. This pediatric case showed no signs of systemic mastocytosis, highlighting localized skin manifestations.

    More Related Videos

    Basophil Activation Test for Allergy Diagnosis
    07:22

    Basophil Activation Test for Allergy Diagnosis

    Published on: May 31, 2021

    9.7K
    Granulocyte-dependent Autoantibody-induced Skin Blistering
    12:23

    Granulocyte-dependent Autoantibody-induced Skin Blistering

    Published on: October 12, 2012

    10.9K

    Related Experiment Videos

    Last Updated: Mar 7, 2026

    Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
    10:27

    Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

    Published on: December 15, 2011

    25.1K
    Basophil Activation Test for Allergy Diagnosis
    07:22

    Basophil Activation Test for Allergy Diagnosis

    Published on: May 31, 2021

    9.7K
    Granulocyte-dependent Autoantibody-induced Skin Blistering
    12:23

    Granulocyte-dependent Autoantibody-induced Skin Blistering

    Published on: October 12, 2012

    10.9K

    Area of Science:

    • Dermatology
    • Pediatrics
    • Pathology

    Background:

    • Urticaria pigmentosa, a form of cutaneous mastocytosis, typically presents with maculopapular lesions.
    • Bullous lesions are an uncommon presentation, particularly in pediatric cases.

    Observation:

    • A 2-year-old child presented with urticaria pigmentosa characterized by prominent bullous lesions.
    • Clinical examination and diagnostic workup were performed to assess the extent and nature of the lesions.

    Findings:

    • The patient exhibited urticaria pigmentosa with distinct bullous formations.
    • Crucially, no evidence of systemic mastocytosis was detected, indicating a localized cutaneous process.

    Implications:

    • This case expands the clinical spectrum of urticaria pigmentosa in children.
    • It underscores the importance of differentiating localized cutaneous disease from systemic involvement in pediatric mastocytosis.