[Statistical analysis of Marfan's syndrome].

Area of Science:

• Ophthalmology
• Genetics
• Medical Research

Context:

• Marfan syndrome is a genetic disorder affecting connective tissue.
• Ocular complications significantly impact vision in Marfan syndrome patients.

Purpose:

• To identify and analyze the ocular complications of Marfan syndrome.
• To determine the relationship between lens dislocation and severe visual impairment.

Summary:

• Retrospective analysis of 104 Marfan syndrome patients (208 eyes).
• Lens dislocation (72.6%) is the most common ocular finding.
• Retinal detachment (36.4%) and glaucoma (15.2%) are primary causes of severe vision loss (<0.1 acuity).
• Downward lens dislocation is associated with glaucoma; horizontal dislocation with retinal detachment.
• Retinal detachment is more common in aphakic eyes.

Impact:

• Highlights retinal detachment and glaucoma as critical vision-threatening complications.
• Informs clinical management and surgical decision-making for lens dislocation in Marfan syndrome.
• Emphasizes the need for cautious surgical intervention in affected individuals.